Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.

Adjuvant sunitinib confers overall survival advantage in primary uveal melanoma

09 Oct 2017

The use of sunitinib in the adjuvant setting improves overall survival in high-risk patients with primary uveal melanoma, a study has found.

Using data from the Wills Eye Hospital Oncology Service Uveal Melanoma Cytogenetic Database, researchers identified 54 uveal melanoma patients (median age 56 years; 48 percent male) who received adjuvant sunitinib for 6 months, and 74 controls (median age 62 years; 48 percent male) presenting the same risk factors.

Inclusion criteria were monosomy 3 and 8q amplification by cytogenetic or DecisionDx-UM Class 2, and monosomy 3 and large tumour size (T3 to 4).

Compared with controls, sunitinib-treated patients had worse cytogenetic or molecular features (monosomy 3 and 8q amplification or class 2, 87 vs 57 percent; p<0.001), had smaller tumour sizes (T3 to 4 56 vs 83 percent; p=0.001) and were younger.

A total of 51 deaths were reported over a median follow-up of 52.7 months, including 14 (26 percent) in the sunitinib group and 37 (50 percent) in the control group.

In a univariate Cox proportional hazards model, the primary endpoint of overall survival was longer in the sunitinib group vs controls (hazard ratio, 0.53; 95 percent CI, 0.29 to 0.99; p=0.041). Adjusting for potential confounders, a significant interaction between use of sunitinib and age was detected (p=0.003).

Significant predictors of overall survival included cytogenetic/molecular status (p=0.015), T-size category (p=0.022), gender (p=0.040) and use of adjuvant sunitinib in patients aged <60 years (p=0.004). Results were confirmed by propensity score analysis.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.