Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.

Adjuvant chemotherapy does not improve survival in node-positive luminal A breast cancer

12 Jul 2017

Endocrine therapy alone may decrease morbidity in node-positive, luminal A breast cancer patients, a new retrospective study shows. Adjuvant chemotherapy, on the other hand, may confer only minimal benefits.

There was no significant difference in the overall survival of node-positive, luminal A breast cancer patients who received endocrine therapy alone (n=50; median age 58.7±11.7 years) and those who received adjuvant chemotherapy (n=642; median age 58.3±9.5 years;hazard ratio [HR], 4.565; 95 percent CI, 0.59 to 40.947; p=0.175).

In contrast, pathologic node stage (HR, 3.715; 0.807 to 17.106; p=0.092) and progesterone receptor (PR) status (HR, 8.627; 1.646 to 45.216; p=0.011) were both associated with overall survival, according to multivariable analysis.

Similarly, adjuvant chemotherapy did not significantly impact disease-free survival (DFS) in node-positive luminal A breast cancer patients (HR, 2.420; 0.554 to 1.0567; p=0.240). On the other hand, nuclear grade (p=0.032), PR status (p=0.001) and radiotherapy (p=0.025) all significantly influenced DFS.

The 50 women on endocrine therapy alone were matched by propensity score to a maximum of 8 women who received adjuvant chemotherapy, yielding a comparison group of 642. There were no significant differences between the groups in terms of demographic factors, tumour factors and pathologic findings.

Patients receiving treatment for invasive breast cancer were recruited from the Samsung Medical Centre. Tamoxifen or aromatase inhibitors were used for the endocrine therapy. Adjuvant chemotherapy included regimens such as doxorubicin with cyclophosphamide, paclitaxel, docetaxel and 5-fluorouracil.

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Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.