Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.

Adiponectin ups risk of proteinuria in lupus

23 Sep 2017
Kidney failures and organ donors: Singapore

Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

In the study cohort of 103 female SLE patients (mean age 43 years), the levels of adiponectin and the adiponectin to body mass index (BMI) ratio were both significantly higher than in the control group (n=83; p<0.001).

In contrast, leptin levels (p=0.09) and leptin to BMI ratio (p=0.08) were only marginally significantly higher in the SLE patients compared with controls.

The SLE patients were further divided into two according to renal activity status: those with (n=30) and those without (n=73) proteinuria.

Both adiponectin levels (20.4 vs 15.6 µg/mL; p=0.02) and adiponectin to BMI ratio (0.8 vs 0.6; p=0.02) were significantly higher in patients with proteinuria than in SLE patients without renal involvement. Again, leptin levels and the leptin to BMI ratio were only marginally higher in those with proteinuria.

Serum adiponectin levels were also significantly correlated with a high degree of proteinuria (p=0.001) and high SLE disease activity index (SLEDAI; p=0.05) and renal-SLEDAI (p=0.002) scores. Serum creatinine (p=0.05) and corticosteroid dose (p=0.03) were also significantly associated with serum adiponectin.

Logistic regression analysis showed that the risk of proteinuria in SLE patients was significantly higher in those with higher level of adiponectin (odds ratio, 1.06; 95 percent CI, 1.01 to 1.12; p=0.02). Serum leptin levels did not significantly affect the risk of proteinuria.

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Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.