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Add-on phentermine enhances weight loss in obese teens

11 Jan 2017

Short-term use of the norepinephrine reuptake inhibitor phentermine in addition to standard of care (SOC) lifestyle modification therapy may lead to greater weight loss in adolescents with obesity compared with SOC alone, according to a study.

Researchers examined the medical records of obese adolescents treated in a paediatric weight management clinic to examine the effect of using phentermine as an add-on to SOC lifestyle modification therapy. The population comprised 25 patients (mean age 16.1 years; mean BMI, 41.2 kgm−2) receiving phentermine plus SOC and 274 patients (mean age 14.9 years; mean BMI, 38.1 kgm−2) receiving only SOC.

The patients were evaluated at 1, 3 and 6 months using generalized estimated equations to determine the differences between the two treatment interventions. Age, sex and BMI were included in the analysis as potential confounders. Robust variance standard error estimates were used to calculate confidence intervals and p-values.

Results showed that the percent change in BMI overall was greater in the phentermine group than in the SOC-only group. The respective changes at 1, 3 and 6 months were −1.6 percent (95 percent CI, −2.6 to −0.6; p=0.001), −2.9 percent (−4.5 to −1.4; p<0.001) and −4.1 percent (−7.1 to −1.0; p=0.009).

There were no significant intergroup differences in systolic or diastolic blood pressure. However, heart rate was higher in patients receiving phentermine plus SOC at all time points.

Given the present data and phentermine’s long track record without major safety concerns, the norepinephrine reuptake inhibitor is a viable treatment option for paediatric obesity.

Further investigation should be conducted regarding the efficacy of phentermine as a monotherapy or in combination with other medications in paediatric obesity, researchers said. Future clinical trials should explore potential mechanisms of action and predictors of response, as well as include additional endpoints such as changes in cardiometabolic risk factors, quality of life and noninvasive vascular measurements.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.