Most Read Articles
20 Jul 2017
Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA, according to a study.
22 Jun 2017
Compared with other models of care, nurse-led care (NLC) for patients with rheumatoid arthritis (RA) is effective, acceptable and safe, according to a recent study. However, current evidence is limited to draw conclusions on its accessibility, appropriateness and efficiency.
Tristan Manalac, 20 May 2017
Global postural re-education (GPR) can moderately improve pain and function in spinal disorders especially when performed during intermediate follow-ups instead of immediately after initial treatment, a new meta-analysis reports.
Dr. Joseph Delano Fule Robles, 23 Jun 2017

Vobarilizumab, a nanobody consisting of an anti-interleukin 6 (IL-6) receptor domain developed for the treatment of rheumatoid arthritis (RA), is shown to be safe and efficacious in RA patients with inadequate response to methotrexate in a study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 held recently in Madrid, Spain.

Adalimumab plus MTX effective in JIA-associated uveitis

20 May 2017

Combination therapy with methotrexate (MTX) and adalimumab, a human anti–tumour necrosis factor α monoclonal antibody, is effective in the treatment of juvenile idiopathic arthritis (JIA)-associated uveitis, according to a recent report.


In the multicentre, double-blind study, researchers assessed the efficacy and safety of adalimumab in children and adolescents ≥2 years of age who had active JIA-associated uveitis and who were receiving a stable dose of MTX. The children were randomized in a 2:1 ratio to receive subcutaneous adalimumab (20 or 40 mg based on body weight) or placebo every 2 weeks until treatment failure or until 18 months had elapsed. They were followed-up for 2 years from the time of randomization. The primary endpoint was time to treatment failure.


The trial was halted early when the prespecified stopping criteria were met after the enrolment of 90 of 114 patients. It was clear that the therapy was effective as the treatment failure rate was 27 percent among adalimumab recipients but 60 percent among those in the placebo group (hazard ratio (HR), 0.25, 95 percent confidence interval (CI) 0.12–0.49; p<0.0001 (this HR was the prespecified stopping boundary). However, the rates of adverse events (10.07 events/patient-year vs 6.51 events/patient-year) and serious adverse events (0.29 events/patient-year vs 0.19 events/patient-year) were also higher among adalimumab recipients. 

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Most Read Articles
20 Jul 2017
Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA, according to a study.
22 Jun 2017
Compared with other models of care, nurse-led care (NLC) for patients with rheumatoid arthritis (RA) is effective, acceptable and safe, according to a recent study. However, current evidence is limited to draw conclusions on its accessibility, appropriateness and efficiency.
Tristan Manalac, 20 May 2017
Global postural re-education (GPR) can moderately improve pain and function in spinal disorders especially when performed during intermediate follow-ups instead of immediately after initial treatment, a new meta-analysis reports.
Dr. Joseph Delano Fule Robles, 23 Jun 2017

Vobarilizumab, a nanobody consisting of an anti-interleukin 6 (IL-6) receptor domain developed for the treatment of rheumatoid arthritis (RA), is shown to be safe and efficacious in RA patients with inadequate response to methotrexate in a study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 held recently in Madrid, Spain.