Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Aberrant EGFR-ASAP1 signalling enhances hepatoblastoma invasiveness

04 Jan 2017

EGFR-ASAP1 signalling may contribute to hepatoblastoma (HBL) tumorigenesis and invasiveness, say US-based researchers.

In their study, they used whole tumour transcriptome sequencing of 10 HBL tumours sourced from children with unresectable HBL requiring transplantation as well as immunohistochemistry analyses of residual formalin-fixed paraffin-embedded tissue samples from 60 children with HBL tumours (39 of which were resectable) to determine whether EGFR, ASAP1, ERBB2, or ERBB4 were predictive of the invasiveness of HBL tumours. [Sci Rep 2016;6:38347]

HBL tumours requiring transplantation were found to be enriched for most cancer signalling pathways, including Wnt-β-catenin, EGF, and ERBB. Compared with well-differentiated foetal cells, a progressive loss in EGFR and ASAP1 expression was observed in less differentiated embryonal and undifferentiated small cells (SCU). This trend was exaggerated in unresectable locally invasive or metastatic tumours: embryonal cells were EGFR-negative and SCU were both EGFR- and ASAP1-negative.

The researchers concluded that their findings indicate that loss of EGFR-ASAP1 signalling is characteristic of undifferentiated and invasive HBL and, if validated in future prospective studies, may facilitate the development of a novel immunohistochemistry panel for individualized risk stratification of HBL tumours.

 

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.