Concomitant statin therapy was associated with an attenuation of tocilizumab (TCZ)-mediated increase in serum lipids in patients with rheumatoid arthritis (RA), according to a recent post hoc analysis of randomized clinical studies.
Patients with early rheumatoid arthritis (RA) may benefit from the initial addition of certolizumab pegol (CZP) to optimized methotrexate (MTX) therapy, as this strategy potentially prevents joint destruction, according to the results of the phase III C-OPERA* study.
The addition of prednisone to methotrexate (MTX)-based treat-to-target strategy for early rheumatoid arthritis (RA) leads to a lower initiation rate of a first biological disease-modifying antirheumatic drug and a significant improvement in radiographic outcomes, a study has shown. Furthermore, prednisone use does not increase the incidence of long-term glucocorticoid-related comorbidities.
Fidaxomicin shows potential for treating Clostridium difficile infection (CDI), with response and recurrence being significantly better in patients with a first CDI episode than in those with prior episodes, according to data from an open-label study.