Targeting mast cells with imatinib, which inhibits the receptor tyrosine kinase KIT, may decrease airway hyperresponsiveness and improve symptoms in patients with severe, poorly controlled asthma, according to a proof-of-principle clinical trial.
The risk of respiratory syncytial virus hospitalization (RSVH) and respiratory-related illness hospitalization (RIH) does not significantly differ between the first and second year of life in paediatric patients with haemodynamically significant congenital heart disease (HSCHD), a new study shows.
The next-generation ALK inhibitor brigatinib yielded high and durable responses in both whole-body and intracranial endpoints, with a median progression-free survival (PFS) of over 1 year in patients with ALK-positive non-small cell lung cancer (NSCLC) whose disease had progressed after crizotinib, according to the ALTA* trial.
While the incidence rate of acute respiratory distress syndrome (ARDS) in Singapore is comparable to the reported values in Europe, the compliance with protective ventilation parameters was inadequate, a new observational study reports.
Strength exercises with both arms raised above the shoulders pose a serious challenge to patients with chronic obstructive pulmonary disease (COPD) compared with other exercise variations, a study has found. Double-arm elevation above shoulder level particularly increases symptoms and cardiovascular demand, as well as delays heart rate (HR) recovery.
The presence of whooping or post-tussive vomiting should rule in a possible diagnosis of pertussis in adult patients, but a diagnosis should be ruled out in the absence of a paroxysmal cough or the presence of fever, according to a meta-analysis. In paediatric patients, on the other hand, post-tussive vomiting is not as useful as a clinical diagnostic test.
The common cold is one of the most widespread illness and is a leading cause of visits to the doctor and absenteeism from school and work. While many may see it as merely a harmless inconvenience, the significant repercussions it brings, especially among children cannot be denied. MIMS JPOG recently spoke to Associate Professor Datin Dr Asmiati Abd Hamid to gain her perspectives on the role of zinc and vitamin C in treating paediatric common cold to reduce morbidity and economic losses attributed to the condition.
The second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) dacomitinib improved progression-free survival (PFS) by an additional 5 months compared with gefitinib in patients with EGFR-positive non-small cell lung cancer (NSCLC), according to results of the open-label, phase III ARCHER 1050* trial.
Tiotropium Respimat is superior over Handihaler in improving time of sleep spent with sleeping oxygen saturation below 90 (TST90) and sleep parameters in patients with chronic obstructive pulmonary disease (COPD) as performed in a randomised, open-label, parallel group trial.
The BRAF inhibitors vemurafenib and dabrafenib, currently approved for use in advanced melanoma, are also effective in a subset of lung adenocarcinoma patients with BRAF mutations, according to a retrospective European trial presented at the European Lung Cancer Conference (ELCC) held in Geneva, Switzerland.