Use of varenicline and bupropion, medication to help quit smoking, is unlikely to be associated with increased risks of cardiovascular (CV) and neuropsychiatric adverse events compared with nicotine replacement therapy (NRT) in smokers with chronic obstructive pulmonary disease (COPD), in contrast to previous belief.
Adding doxycycline to prednisolone did not appear to improve time to exacerbation in patients with mild-to-severe chronic obstructive pulmonary disease (COPD) treated in an outpatient setting, according to a study from the Netherlands.
The rapidly growing elderly population of Singapore is a major risk factor contributing to the recent rise in tuberculosis (TB) cases in the country, a new study reveals. This may lead to further increases in incidence despite improving TB monitoring and management mechanisms.
It appears that prescribing immediate antibiotics does not lessen major adverse outcomes of subsequent hospital admission or death for young people and adults with uncomplicated lower respiratory tract infection, a recent study has shown.
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.
Fixed-dose combinations of long-acting β2-agonist (LABA) and muscarinic antagonist (LAMA) offered superior efficacy and comparable safety to LAMA or LABA/inhaled corticosteroid (ICS), the two most commonly prescribed first-line treatments for stable moderate-to-very-severe chronic obstructive pulmonary disease (COPD), according to a meta-analysis.
There is no evidence suggesting that genetically determined decrease in 25-hydroxyvitamin D (25OHD) levels confers an elevated risk of asthma, atopic dermatitis or elevated total serum immunoglobulin E (IgE), according to a recent study.
Third-generation EGFR tyrosine kinase inhibitors (TKIs) designed to overcome the T790M mutation have been shown to double progression-free survival (PFS) of patients with advanced non-small-cell lung cancer (NSCLC) harbouring activating EGFR mutations, according to reports at the European Lung Cancer Conference (ELCC) 2016 held recently in Geneva, Switzerland.
Umeclidinium/vilanterol improves SGRQ total score and decreased rescue albuterol use in patients with chronic obstructive pulmonary disease (COPD), as observed in a 12-week multicentre, randomised, double-blind, parallel-group, placebo-controlled study.
Fluticasone furoate-vilanterol combination increases trough forced expiratory volume in 1 second compared with fluticasone furoate-fluticasone propionate in patients with symptomatic asthma, as stated in a systemic review with meta-analysis of seven published randomised clinical trials.