S-1* combination therapy was associated with a higher response rate and longer progression-free survival (PFS) than S-1 monotherapy in patients with gemcitabine-refractory advanced pancreatic cancer, a new meta-analysis has found.
The addition of lesinurad to febuxostat appears to provide superior serum urate-lowering benefit compared with febuxostat alone, with acceptable safety profile and clinically significant effect on tophi, in patients with tophaceous gout requiring additional therapy, according to the results of a 12-month, phase III trial.
Dr Ravichandran Nadarajah, a consultant at the Department of Obstetrics & Gynaecology, Singapore General Hospital, speaks to Roshini Claire Anthony on the significant role played by GPs in ensuring early diagnosis and prevention of cervical cancer.
The efficacy of scheduled intravenous (IV) proton pump inhibitors (PPIs) are comparable to that of IV PPI drip for most outcomes in acute nonvariceal upper gastrointestinal bleeding (ANVGIB), a recent systematic review and meta-analysis has found. Moreover, oral PPIs are as effective as scheduled IV for length of stay (LOS) and total units of blood transfused (UBT) and superior to IV PPI drip for risk of surgery (ROS).
Treatment with direct-acting antiviral regimens and attainment of sustained virologic response (SVR) are associated with a significant mortality benefit, which is evident within the first 18 months of treatment, in patients with hepatitis C virus (HCV) infection, a study has found.
Individuals with Parkinson’s disease of moderate severity experienced improvement in motor symptoms following 48 weeks of treatment with the glucagon-like peptide-1 (GLP-1) receptor agonist exenatide, according to results of a small study.
High consumption of fish and egg appears to be negatively associated with successful Helicobacter pylori eradication therapy in H. pylori‒positive patients with gastritis and/or duodenal ulcers, a recent study has found.
Golimumab appears to induce rapid, clinically meaningful improvements in children with active polyarticular-course juvenile idiopathic arthritis (polyJIA), according to the results of a trial that did not meet its primary endpoint.
Treatment with tofacitinib appears to increase the risk of herpes zoster (HZ) compared with placebo, according to a recent study. The risk factors for heightened risk are Asian descent, increasing age, higher dose and prior biologic exposure.
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
Adding midostaurin to standard chemotherapy appeared to improve overall survival (OS) in patients recently diagnosed with acute myeloid leukaemia (AML) with a FLT3 mutation, according to a recent study.
Celecoxib is preferred over naproxen when added to proton-pump inhibitor (PPI) for preventing recurrent upper gastrointestinal (GI) bleeding in patients at high risk of both GI and cardiovascular (CV) events, who require concomitant aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), according to the CONCERN* study.