Adding doxycycline to prednisolone did not appear to improve time to exacerbation in patients with mild-to-severe chronic obstructive pulmonary disease (COPD) treated in an outpatient setting, according to a study from the Netherlands.
A new guideline on when to deprescribe proton pump inhibitors (PPIs) in the setting of gastroesophageal reflux disease (GERD) and other upper gastrointestinal (GI) symptoms will guide clinicians’ treatment decisions amid increasing concerns over PPI overuse.
It appears that prescribing immediate antibiotics does not lessen major adverse outcomes of subsequent hospital admission or death for young people and adults with uncomplicated lower respiratory tract infection, a recent study has shown.
Patients with stable schizophrenia may benefit from long-term antipsychotic treatment, with a recent meta-analysis finding that continuation of antipsychotics over a 1-year period significantly reduces symptom exacerbation in this population in contrast to a trajectory of continuous symptom exacerbation in patients on placebo.
Timely and active treatment for bloodstream infections caused by carbapenemase-producing Enterobacteriaceae (CPE) is associated with lower mortality risk, according to a recent study. Moreover, only patients with a high risk of death appear to benefit from combination therapy.
The Micra leadless transcatheter pacing system (TPS) demonstrates a high implant success rate of 99.6 percent with low major complication rate at 30 days after implantation in real-world patients, which appears to surpass its performance observed in the IDE* trial that drove its approval, according to an interim analysis of an ongoing prospective postapproval registry.
Pioglitazone may effectively reduce the risk of acute coronary syndrome (ACS) following a cerebrovascular event among patients with insulin resistance (IR) but without diabetes mellitus, with the most prominent effect observed on spontaneous type 1 myocardial infarctions, according to a secondary analysis of the IRIS* trial.
Long-term use of metformin does not negatively impact cognitive performance, according to a new study, giving clinicians and their patients evidence-based reassurance regarding metformin use as a diabetes prevention pill.
New drug applications approved by US FDA as of 1 - 15 February 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Catherine J Calderwood, MA (Cantab), MRCOG; Omar I Thanoon, MRCOG,
3 years ago
One of the many early physiological adaptations of pregnancy involves changes in the coagulation system, which promote coagulation and impair fibrinolysis. The physiological goal is to prepare for the haemostatic challenge of delivery. A ‘side effect’ of this change is an increased risk of thrombosis. All pregnant women are therefore at risk of thrombosis, compared with non-pregnant women. This risk is manifest from early in the first trimester until 4−6 weeks post partum.