Active surveillance on patients with localized prostate cancer results in a decreased rate of active surveillance failure, prostate cancer specific mortality and metastases regardless of baseline risk, according to a recent study.
There are independent patient responses to high-dose interleukin-2 and to targeted agents before and after receiving high-dose interleukin-2, according to a recent study. This suggests that carefully selected patients must be given high-dose interleukin-2 for the possibility of a complete and durable response without the fear of limiting the treatment benefit of targeted agents.
Both denosumab and bisphosphonates enhance bone mineral density (BMD) in men with nonmetastatic prostate cancer who are receiving androgen deprivation therapy (ADT), according to a systematic review and meta-analysis. In addition, denosumab lowers the risk for radiographic vertebral fractures.
A recent study has shown that patients with panurothelial carcinoma who underwent radical cystectomy and then radical nephroureterectomy with locally advanced disease in a large proportion have poor prognosis.
Increased white blood cell count and decreased relative lymphocyte count are associated with serious adverse events (AEs) such as grade 3/4 or lung/gastrointestinal immune-related AEs in nivolumab-treated patients with melanoma, a study has found.
Starting radiation therapy (RT) shortly after breast-conserving surgery does not appear to yield improvements in long-term outcome, bringing into question the common position that RT should be initiated as soon as possible following surgery so as to increase treatment efficacy in breast cancer patients, according to a recent study.
A high burden of metabolic risk factors may increase the risk of hepatocellular carcinoma (HCC) in men with chronic hepatitis B virus (HBV) infection, a study has shown. Importantly, smoking exerts a significant effect on the said association.
The combination of nimotuzumab and gemcitabine is safe and well tolerated in the treatment of patients with locally advanced or metastatic pancreatic cancer, significantly improving 1-year overall survival and progression-free survival rates especially in those with KRAS wild-type tumours, according to a study.
Maintenance therapy with vinflunine in patients with advanced transitional-cell carcinoma of the urothelial tract affords better progression-free survival (PFS) compared with best supportive care alone, with the drug demonstrating an acceptable toxicity profile, according to data from a phase II study.
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are superior to chemotherapy as first-line therapy for advanced non-small cell lung cancer (NSCLC) with positive EGFR gene mutations in terms of progression-free survival rates, says an expert.
A study reveals yet another benefit with regular aspirin use, this time showing a reduction in the long-term risk of hereditary colorectal cancer (CRC) in obese patients with Lynch syndrome (LS), a condition caused by mutations in the mismatch repair (MMR) genes.
Pneumonitis is a rare but potentially fatal side effect of immune checkpoint antibodies that target the programmed death-1 receptor and programmed death-ligand 1 [PD-1/PD-L1] pathway, and clinical caution is recommended in order to deliver appropriate urgent treatment.