White matter (WM) integrity in HIV-infected children is compromised despite early antiretroviral therapy (ART) and viral load (VL) suppression, with damage persisting at 5 years of age and evidence of new damage present, a recent study has shown.
Increasing evidence points to a link between hypertension and cognitive decline, particularly in the elderly population, according to a presentation at APCH 2017. However, the impact of antihypertensive medication use on dementia incidence is unestablished.
New drug applications approved by US FDA as of 1 - 15 October 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
The CHANGE (chronic lacunes, hyperintensities, age, nonlacunar cortical infarcts, global atrophy and education) score is a newly developed tool that can reliably identify patients with risks of poststroke cognitive impairment, (PSCI) a new study has found.
Once-monthly and once-quarterly administration of paliperidone palmitate had similar efficacy in terms of relapse prevention for schizophrenia in an East Asian population, according to a subgroup analysis.
Intracerebral haemorrhage with direct oral anticoagulants (DOACs) appears to be related to smaller baseline haematoma volumes and less neurological deficit than that with vitamin K antagonists (VKAs), reveals a recent study.
Type 2 diabetes mellitus (T2DM) and impaired renal function are both independently related to abnormal brain structure, as well as poorer cognitive test performance at year 2 following stroke, according to the TABASCO* study.
New drug applications approved by US FDA as of 1 - 15 September 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.