Unrestricted access to direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection in individuals with HIV led to a substantial reduction in HCV incidence, particularly in the key subgroup of men who have sex with men (MSM), according to a retrospective Dutch study.
Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) did not result in worsening renal function or bone mineral density (BMD) in Asian patients with chronic hepatitis B virus (HBV) infection, according to a small real-world prospective study.
Use of prescription opioids in early pregnancy does not appear to significantly increase the risk of certain congenital malformations, a recent study has found. However, an association is observed with a slightly elevated risk of oral clefts.
Sleep experts warned that lack of sleep among teens can adversely impact their well-being across the board, including physical and mental health, and that too much time spent on device is a culprit displacing normal sleep time of teens, as reported in a review article.
Sipping green tea and coffee may add years
to the life expectancy of adults, according to a study from Japan. The former
helps brighten the outlook of stroke or myocardial infarction (MI) survivors;
the latter produces the same effect but also in people without a history of the
Antihypertensive treatment is not associated with falls or fractures but appears to result in mild (eg, hyperkalaemia, hypotension) and severe adverse events (eg, acute kidney injury, syncope), according to a systematic review and meta-analysis. Moreover, some effects are specific to the drug class used.
Long, irregular menstrual cycles across the reproductive life span is associated with a greater risk of developing type 2 diabetes (T2D) in women, particularly among those who are overweight or obese, physically inactive, and had poor eating habits, a prospective study has shown.
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Treatment with tanezumab appears to relieve pain and improve physical function in patients with hip or knee osteoarthritis (OA), but may lead to dose-dependent increase in joint safety events as compared with nonsteroidal anti-inflammatory drug (NSAID), according to the results of a phase III safety trial.