Dr. Hang Wun Raymond Li, Prof. Pak-Chung Ho, Dr. Ernest Hung Yu Ng, 20200317000000
Anti-Müllerian hormone (AMH) was initially recognized as the factor that
determines regression of the Müllerian duct in the male foetus and
hence plays an important role in male sex differentiation. Production of
AMH in adult women was first reported in 1990.1 In the past two
decades, its role in female ovarian function and the clinical utilities
of serum AMH level has been increasingly studied.
Dr. Daniel Chan, Assoc Prof. Daisy Kwai-Lin Chan, 20200312000000
Hypoglycaemia is one of the most common clinical issues facing newborn
babies. It can be caused by abnormalities in the glycogen stores,
alternative substrates, and/or functioning enzymes. The definition of
neonatal hypoglycaemia itself remains challenging. Understanding normal
glucose physiology and biochemistry is important so that the
neonatologist can initiate appropriate investigations to elucidate an
aetiology and institute correct management. Early diagnosis and prompt
treatment of hypoglycaemia will reduce the risk of brain injury to the
Dr. Kubi Appiah, Dr. Piya Chaemsaithong, Dr. Liona Chiu Yee Poon, 20191129085839
Preterm birth (PTB) is birth that occurs before 37 weeks’ gestation, and it is a leading cause of perinatal morbidity and mortality.1 Babies born before 34 weeks’ gestation are particularly associated with high rates of morbidity and mortality.2 They are also at risk of long-term medical and social sequelae.3 It is therefore important to institute preventative measures that can help mitigate the occurrence of PTB in pregnant women.
Dr. Xian Li, Dr. Hang Wun Raymond Li, Dr. Shui Hua Lin, Prof. Pak-Chung Ho, 20190312084537
Endometrial polyp (EP) is a frequently encountered gynaecologic condition that may present with abnormal vaginal bleeding. It can also be asymptomatic and detected incidentally during imaging investigations or hysteroscopy for infertility or other conditions. Most EPs are benign, but premalignancy or even malignancy may occasionally occur.
Teng Sung Shin, Joyce Lam Ching Mei, 20180903000000
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Thrombocytopenia, defined as a platelet count of less than 150,000/microL, is clinically suspected when there is a history of increased bruising or bleeding, or when there is petechiae noted which is often referred to as a “rash”. Thrombocytopenia is usually asymptomatic until platelet counts fall below 50,000/microL, and may also be detected incidentally in a full blood count (FBC) during routine evaluation of an asymptomatic patient or during investigations performed for other reasons.1
Genetic diseases cause great physical effect to newborns and psychological impact to parents. Recessive genetic diseases can hit asymptomatic carrier couples with detrimental impact because very often they are not aware of their carrier status. Recessive genetic disease affects at least 30 in every 1,000 children, ranging from very mild to severe phenotype.1-2 Common examples of recessive genetic diseases include thalassaemia, spinal muscular atrophy, congenital adrenal hyperplasia, cystic ﬁbrosis, among others.
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Treatment with tanezumab appears to relieve pain and improve physical function in patients with hip or knee osteoarthritis (OA), but may lead to dose-dependent increase in joint safety events as compared with nonsteroidal anti-inflammatory drug (NSAID), according to the results of a phase III safety trial.