It appears that prescribing immediate antibiotics does not lessen major adverse outcomes of subsequent hospital admission or death for young people and adults with uncomplicated lower respiratory tract infection, a recent study has shown.
Timely and active treatment for bloodstream infections caused by carbapenemase-producing Enterobacteriaceae (CPE) is associated with lower mortality risk, according to a recent study. Moreover, only patients with a high risk of death appear to benefit from combination therapy.
The updated, evidence-based guidelines for prevention of surgical site infections (SSIs) recently released by the CDC* aims to help minimize the occurrence of SSIs, while highlighting areas that require further research.
Levels of interleukin (IL)-6 in the synovial fluid has significant diagnostic value for prosthetic joint injuries (PJI), especially in periprosthetic infections in the hip and knee, reports a new meta-analysis. Moreover, serum IL-6, although less sensitive, has high specificity and may also help diagnose prosthetic failure.
A twice-daily oral dose of tofacitinib resulted in higher remission rates compared with placebo in patients with moderate-to-severe ulcerative colitis (UC), with efficacy maintained at 52 weeks, according to the results of three phase III, multicentre, double-blind trials.
A wide spectrum of neurological manifestations, including some unusual neurological disease presentations, has been identified in Singaporean children with enterovirus infections, according to a recent study. This results in a relatively low incidence of long-term neurological sequelae.
Chinese researchers have reported the first fatal case of human infection with a novel H10N8 avian influenza virus, but the source of infection remains unknown. [Lancet 2014, e-pub 5 Feb, doi: 10.1016/50140-6736(14)60111-2]