Female patients taking long-term proton pump inhibitors (PPIs) have threefold odds of tolerating half of their prior dose, suggesting that the female gender is associated with an increased probability for successful step-down, according to a recent study.
Elevated serum concentrations of C-reactive protein (CRP) during clinical remission are associated with hospitalization and associated intestinal resection in Crohn’s disease (CD) patients, a new study shows.
Tests for serum tissue transglutaminase (tTG) and endomysial antibodies (EMA) demonstrate low sensitivity for identifying persistent villous atrophy in patients with biopsy-confirmed coeliac disease undergoing follow-up biopsy on a gluten-free diet (GFD), according to a meta-analysis.
The vonoprazan-based triple therapy is superior to proton pump inhibitor-based triple therapy in terms of Helicobacter pylori eradication, although the two regimens show comparable tolerability and incidence of adverse events, according to a review and meta-analysis.
Patients with inflammatory bowel disease (IBD) who are treated with corticosteroids, immunosuppressants and biologics have a low risk of pneumonia caused by Pneumocystis jirovecii (PJP), a population-based cohort study has shown. This suggests that routine administration of PJP prophylaxis in this population may not be warranted.
Larotrectinib delivers durable response across diverse cancer types, including paediatric and adult cancers, according to an interim analysis of three ongoing trials presented at the ASCO 2017 Annual Meeting.
Saccharomyces boulardii has favourable safety and efficacy in the treatment of children aged 3 months to 5 years with acute rotavirus diarrhoea, based on a double-blind, randomised controlled trial from a developing country.