A new guideline on when to deprescribe proton pump inhibitors (PPIs) in the setting of gastroesophageal reflux disease (GERD) and other upper gastrointestinal (GI) symptoms will guide clinicians’ treatment decisions amid increasing concerns over PPI overuse.
The plasma-free amino acid (PFAA) profile predicts dyslipidaemia, hyperinsulinaemia and hyperglycaemia in healthy Singaporean adults, a new cross-sectional study reveals. Moreover, changes in this profile are correlated with central adiposity.
A genetic variant in the tolloid like 1 (TLL1) gene is strongly associated with the development of hepatocellular carcinoma (HCC) after the eradication of hepatitis C virus (HCV) infection by interferon-based therapy, according to a genome-wide association (GWAS) study.
A twice-daily oral dose of tofacitinib resulted in higher remission rates compared with placebo in patients with moderate-to-severe ulcerative colitis (UC), with efficacy maintained at 52 weeks, according to the results of three phase III, multicentre, double-blind trials.
Celecoxib is preferred over naproxen when added to proton-pump inhibitor (PPI) for preventing recurrent upper gastrointestinal (GI) bleeding in patients at high risk of both GI and cardiovascular (CV) events, who require concomitant aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), according to the CONCERN* study.
Adolescent males with a high body mass index (BMI) appear to be at a greater risk of severe liver disease including hepatocellular carcinoma (HCC), and this risk is more pronounced in men who develop type 2 diabetes mellitus (T2DM), according to a population-based cohort study.
Use of plecanatide in the treatment of chronic idiopathic constipation appears to induce notable improvements in bowel movement frequency, stool consistency, and straining and abdominal symptoms, with a low incidence of adverse events, according to the results of a phase III trial.
Switching to esomeprazole improves reflux symptoms and quality of life (QoL) in Japanese patients with gastroesophageal reflux disease (GERD) who are refractory to conventional proton pump inhibitors (PPIs), a Japanese study has shown.
Public awareness of the specific alarm symptoms of upper gastrointestinal (GI) cancer are not very prevalent, and healthcare-seeking behaviour regarding the disease remains poor, according to a recent study.
Saccharomyces boulardii aids in lowering Helicobacter pylori colonisation in the gastrointestinal system of asymptomatic primary school children, as reported in a randomised, double-blind, placebo-controlled clinical trial.