Achieving a stringent glycated haemoglobin (HbA1c) goal of <6.5 percent within 6 months of metformin initiation was associated with a decreased risk of cardiovascular (CV) events and mortality in real-world patients with type 2 diabetes, with a greater magnitude of HbA1c reduction being predictive of a lower outcome risk, according to a large Danish registry-based study.
The plasma-free amino acid (PFAA) profile predicts dyslipidaemia, hyperinsulinaemia and hyperglycaemia in healthy Singaporean adults, a new cross-sectional study reveals. Moreover, changes in this profile are correlated with central adiposity.
Pioglitazone may effectively reduce the risk of acute coronary syndrome (ACS) following a cerebrovascular event among patients with insulin resistance (IR) but without diabetes mellitus, with the most prominent effect observed on spontaneous type 1 myocardial infarctions, according to a secondary analysis of the IRIS* trial.
Long-term use of metformin does not negatively impact cognitive performance, according to a new study, giving clinicians and their patients evidence-based reassurance regarding metformin use as a diabetes prevention pill.
Researchers have reported that pancreatic islet cells transplanted within a tissue-engineered platform located in the omentum of a young woman with type I diabetes (T1D) successfully engrafted and resulted in the achievement of insulin independence. The report provides proof-of-concept confirmation that the novel strategy of transplanting cells within the omentum rather than the liver is an important step forward for restoring natural insulin production in T1D.
Adiposity appears to mediate the association between cardiorespiratory fitness and blood pressure in young adults, according to a study said to be the first to examine such relationship using mediation analysis.
Intravitreal injection of the anti-VEGF* agent aflibercept shows superior visual acuity outcomes over panretinal laser photocoagulation (PRP) at 1 year in eyes with active proliferative diabetic retinopathy (PDR) without diabetic macular oedema, according to the CLARITY** study.
Type 2 diabetes (T2D) appears to be much more aggressive in youths, with beta cell function deteriorating much more quickly than in adults with T2D even with combination treatment, suggested the TODAY* study, key findings of which were presented at the recent ASEAN Federation of Endocrine Societies (AFES) meeting.
Pure oats can be safely included in the gluten-free diet (GFD) of children with coeliac disease, concluded researchers at the recent European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) annual meeting held in Athens, Greece.